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KMID : 0605620120190010053
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Journal of Korean Society of Biological Psychiatry
2012 Volume.19 No. 1 p.53 ~ p.57
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Association Study between DRD2 Genetic Polymorphisms and Schizophrenia in a Korean Population
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Kim Tae-Sung
Cha Seung-Min
Wang Seong-Keun
Kim Jeong-Lan
Lee Young-Ho
Choi Hye-In
Chee Ik-Seung
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Abstract
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Objectives: This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia.
Methods: TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls.
Results: There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls.
Conclusion: These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.
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KEYWORD
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Schizophrenia, DRD2, Genetic polymorphism, Association study
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